Understanding how hemoglobin in brain cells adapts to energy needs
The hemoglobin beta subunit regulates chromatin and transcription to adapt to metabolic demands
['FUNDING_R15'] · KENT STATE UNIVERSITY · NIH-10974639
This study is looking at how a protein called hemoglobin beta subunit (Hbb) helps brain cells manage their energy needs and how exercise might change this process, which could lead to new ideas for treating conditions like Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | KENT STATE UNIVERSITY (nih funded) |
| Locations | 1 site (KENT, UNITED STATES) |
| Trial ID | NIH-10974639 on ClinicalTrials.gov |
What this research studies
This research investigates the role of hemoglobin beta subunit (Hbb) in brain cells, particularly how it influences gene expression and chromatin structure to meet the brain's metabolic demands. The study will utilize advanced techniques like ChIP sequencing to identify where Hbb binds in the genome and which genes it regulates. Additionally, the research will explore how Hbb affects energy metabolism in neurons and the impact of exercise on these processes. By uncovering these mechanisms, the research aims to provide insights into brain function and potential therapeutic targets for conditions like Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurological conditions or those not affected by cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Alzheimer's disease and other neurodegenerative conditions.
How similar studies have performed: While the specific role of hemoglobin in brain cells is less explored, related research has shown promising results in understanding metabolic adaptations in neurons.
Where this research is happening
KENT, UNITED STATES
- KENT STATE UNIVERSITY — KENT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCDONOUGH, JENNIFER — KENT STATE UNIVERSITY
- Study coordinator: MCDONOUGH, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease