Understanding how hemoglobin C trait affects malaria in children in Mali
Malaria variant surface antigen expression and vulnerability to disease in Malian children with Hemoglobin C trait
This study is looking at how having the hemoglobin C trait might help protect children in rural Mali from severe malaria by examining their immune responses and the malaria parasite's surface features.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10642903 on NIH RePORTER |
What this research studies
This research investigates how the hemoglobin C trait influences the severity of malaria in children in rural Mali. It focuses on the variant surface antigens of the malaria parasite, which are believed to play a critical role in disease severity. By studying the immune responses of children with hemoglobin C trait, the research aims to uncover the mechanisms that provide protection against malaria. The study involves analyzing blood samples to assess the expression of these antigens and the corresponding immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years living in rural Mali who possess the hemoglobin C trait.
Not a fit: Patients without the hemoglobin C trait or those outside the targeted age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating malaria in children with hemoglobin C trait.
How similar studies have performed: Previous research has shown that hemoglobinopathies can provide protection against malaria, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Travassos, Mark a — University of Maryland Baltimore
- Study coordinator: Travassos, Mark a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.