Understanding how heme signaling affects aging and lifespan
Official title: Lifespan Regulation by Inter-Organellar Heme Signaling
Funded at Georgia Institute of Technology · NIH-10894272 · Data updated 2026-11-12
This study is looking at how a special molecule called heme affects aging and how long we live, using tiny organisms like yeast and worms to understand how changes in heme levels can influence our health as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $367,829 |
| NIH project number | 5R01AG082807-02 |
| Project ID | NIH-10894272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those with age-related health concerns.
✕Less likely to help
Patients with acute or non-age-related conditions may not benefit from this research.
What this research studies
This research investigates the role of heme, a vital molecule in cells, in regulating aging and lifespan. It aims to uncover how changes in heme levels influence metabolic processes associated with aging, using advanced techniques like genetically encoded sensors and mass spectrometry. By studying model organisms such as yeast and worms, the research seeks to identify the mechanisms through which heme signaling operates and its impact on cellular health and longevity.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and extending lifespan.
How similar studies have gone: Previous studies have shown promising results in extending lifespan through heme regulation in model organisms, indicating potential for success in this area.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Reddi, Amit Ram — Georgia Institute of Technology
- Study coordinator: Reddi, Amit Ram
Related research
Other NIH-funded projects on the same topics.
-
Integrative AI tools to map protein sequences to structures and functions
A scientist team will develop advanced AI methods to better connect protein sequences, their 3D shapes, and how they work, using large biological data from sequencing and structures.
-
Robotic ultrasound-guided clot removal for stroke treatment
A new robot-assisted ultrasound system is being developed to help quickly reopen brain arteries during a stroke, with testing in patient-specific 3D-printed models and animal studies.
-
siRNA nanoparticle treatment to stop diabetic kidney damage
A new nanoparticle-delivered gene-silencing treatment aims to lower kidney inflammation in people with diabetes to help protect their kidneys.
-
Nanosensor blood test to spot early pancreatic cancer fingerprints
This project will use a nanosensor blood test to detect early-stage pancreatic cancer by reading a disease 'fingerprint' in patient serum.
-
Synergistic blood-brain barrier opening and targeted glioma treatment with pulsed electric fields
A new approach uses tiny, rapid electric pulses to safely disrupt the brain's protective barrier and enhance targeted treatment for malignant glioma.
-
Dexterous needle ablation for ventricular arrhythmia guided by MRI
A new MRI-guided, robot-assisted catheter delivers deeper heart tissue ablation to treat ventricular tachycardia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.