Understanding how heme regulation affects health and disease
Official title: Heme-, Redox-, and CO-dependent Regulation of Heme Homeostasis
Funded at University of Michigan at Ann Arbor · NIH-11082405 · Data updated 2026-11-12
This study is looking at how certain proteins help keep heme levels balanced in our bodies and protect our cells from damage, which could lead to better treatments for heart and brain diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $628,925 |
| NIH project number | 5R01HL163530-03 |
| Project ID | NIH-11082405 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cardiovascular diseases or conditions related to oxidative stress.
✕Less likely to help
Patients with conditions unrelated to heme metabolism or oxidative stress may not receive any benefit from this research.
What this research studies
This research investigates the roles of heme oxygenases and Rev-Erbβ in maintaining heme balance and protecting cells from damage caused by excess heme. By exploring how these proteins regulate heme metabolism and signaling, the study aims to uncover their protective effects against various diseases, particularly those affecting the cardiovascular and nervous systems. Patients may benefit from insights into how disruptions in heme regulation can lead to health issues, potentially guiding new treatment strategies. The research employs biochemical assays and cellular models to analyze the interactions and functions of these proteins.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for conditions related to heme imbalance, such as cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding heme regulation and its implications for health, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Ragsdale, Stephen Wiley — University of Michigan at Ann Arbor
- Study coordinator: Ragsdale, Stephen Wiley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.