Understanding how heme is transported within cells
Official title: Defining a pathway for mitochondrial heme trafficking
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10904908 · Data updated 2026-11-12
This study is looking at how a special protein called GAPDH helps move an important molecule called heme around inside our cells, which could help us understand how it affects our heart and immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $536,531 |
| NIH project number | 5R01GM148664-02 |
| Project ID | NIH-10904908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to heme metabolism, such as anemia or autoimmune diseases.
✕Less likely to help
Patients with conditions unrelated to heme transport or metabolism may not benefit from this research.
What this research studies
This research investigates the mechanisms by which heme, a vital molecule for various biological functions, is transported from mitochondria to other parts of the cell. The study focuses on a protein called GAPDH, which is believed to play a crucial role in this delivery process. By using purified proteins and cell cultures, researchers aim to uncover how GAPDH binds to heme and transfers it to different target proteins. This could lead to insights into how heme delivery affects various bodily systems, including cardiovascular and immune functions.
Why it matters
Potential benefit: If successful, this research could improve our understanding of diseases related to heme transport, potentially leading to new treatments for conditions like anemia and autoimmune disorders.
How similar studies have gone: While the specific approach of studying GAPDH in heme transport is novel, similar research has shown that understanding protein interactions can lead to significant advancements in medical science.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Stuehr, Dennis J — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Stuehr, Dennis J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.