Understanding how heme is transported and recycled in the body for iron metabolism
Heme trafficking and recycling in iron metabolism
This study is looking at how our bodies recycle a part of red blood cells called heme, which helps keep our iron levels balanced, and it's especially for people who might be dealing with anemia due to iron deficiency.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10653923 on NIH RePORTER |
What this research studies
This research focuses on the mechanisms of heme transport and recycling, which are crucial for maintaining iron levels in the body. Iron deficiency is a widespread nutritional issue that often leads to anemia, particularly due to the role of heme in hemoglobin production. The study investigates how macrophages in the reticuloendothelial system recycle heme-iron from old or damaged red blood cells, which is then used to create new red blood cells. By exploring the pathways involved in heme transport, the research aims to uncover genetic factors that may contribute to anemia when these processes are disrupted.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults suffering from anemia, particularly those with conditions like sickle cell disease.
Not a fit: Patients who do not have anemia or related iron metabolism disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for anemia and related conditions by enhancing our understanding of iron metabolism.
How similar studies have performed: Previous research has shown promising results in understanding iron metabolism and its implications for anemia, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Hamza, Iqbal — University of Maryland Baltimore
- Study coordinator: Hamza, Iqbal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.