Understanding how HELLS protein helps maintain DNA stability
Administrative Supplement: Role of HELLS chromatin remodeler in genome maintenance
This study is looking at a protein called HELLS to see how it helps keep our DNA stable and healthy, which is important for preventing diseases like cancer, using a type of fungus to learn more about how it works in repairing DNA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11040828 on NIH RePORTER |
What this research studies
This research investigates the role of the HELLS protein in maintaining the stability of DNA, which is crucial for preventing diseases like cancer. By using a fungal model, the study aims to uncover how HELLS influences DNA repair and genome maintenance. The researchers will explore whether HELLS regulates different DNA repair pathways and its specific functions in various genomic regions. This work could provide insights into the mechanisms of DNA repair and how disruptions can lead to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to cancers or those affected by conditions related to DNA repair deficiencies.
Not a fit: Patients with stable, non-genetic conditions unrelated to DNA repair or chromatin remodeling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing DNA repair mechanisms, potentially reducing the risk of cancer and other genetic diseases.
How similar studies have performed: While the specific role of HELLS in DNA repair is not extensively studied, related research on chromatin remodeling has shown promising results in understanding genome stability.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Czaja, Wioletta — University of Alabama at Birmingham
- Study coordinator: Czaja, Wioletta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.