Understanding how Hedgehog signaling affects growth and development in the body.
Hedgehog Signaling in Development and Metabolism
This study is looking at how a special signaling system in our bodies, called the Hedgehog pathway, works and how problems with it might lead to diseases like cancer, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11010937 on NIH RePORTER |
What this research studies
This research investigates the Hedgehog (Hh) signaling pathway, which plays a crucial role in regulating growth and development during both embryonic stages and in adult tissues. By examining how Hh interacts with specific proteins to control cellular processes, the research aims to uncover the mechanisms behind its dysregulation in various diseases, including cancer. The team employs genetic and biochemical methods to explore these signaling pathways, which could lead to new insights into treatment options for conditions linked to Hh signaling abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with basal cell carcinoma or other cancers related to Hedgehog signaling, as well as those with degenerative neurological disorders.
Not a fit: Patients with conditions unrelated to Hedgehog signaling or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other disorders associated with Hedgehog signaling dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding Hedgehog signaling, indicating that this area of study has potential for significant advancements in treatment.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Jia, Jianhang — University of Kentucky
- Study coordinator: Jia, Jianhang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.