Understanding how Hedgehog signaling affects glioblastoma
Mechanisms of Hedgehog signaling in glioblastoma
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11078855
This study is looking at how certain cells in glioblastoma, a tough kind of brain cancer, work with their surroundings to help the tumor grow, and it's for anyone interested in understanding how we might improve treatments for this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11078855 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Hedgehog signaling in glioblastoma, a type of aggressive brain cancer. It aims to uncover how glioblastoma stem cells interact with their surrounding environment and how these interactions influence tumor growth. Using advanced techniques like live imaging and CRISPR technology, the study will explore the cellular mechanisms at play in glioblastoma. By creating a novel astrocyte organoid model, researchers hope to gain insights that could lead to better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who are 21 years or older.
Not a fit: Patients with other types of brain tumors or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating glioblastoma, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown that understanding cellular signaling pathways can lead to significant advancements in cancer treatment, suggesting this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RALEIGH, DAVID R — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: RALEIGH, DAVID R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.