Understanding how Hedgehog signaling affects gene activation in development and cancer.
Official title: Hedgehog signal transduction: mechanism of Ci/Gli transcriptional effector activation
Funded at Columbia Univ New York Morningside · NIH-10809872 · Data updated 2026-11-12
This study is looking at how a specific signaling pathway in our cells, called the Hedgehog pathway, works and how problems with it can lead to developmental disorders and cancers, using fruit flies to help us understand these issues better and find new treatments.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 3, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $152,226 |
| NIH project number | 1R03HD111663-01A1 |
| Project ID | NIH-10809872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with cancers or developmental disorders associated with Hedgehog signaling mutations.
✕Less likely to help
Patients with conditions unrelated to Hedgehog signaling or those not affected by genetic mutations in this pathway may not benefit from this research.
What this research studies
This research investigates the Hedgehog (Hh) signaling pathway, which plays a crucial role in development and stem cell regulation in both fruit flies and humans. By studying the molecular mechanisms that activate transcription factors involved in this pathway, the research aims to uncover how genetic changes can lead to developmental disorders and various cancers. The approach involves using Drosophila as a model organism to explore the connections between key proteins in the signaling pathway, which could lead to the development of targeted therapies for conditions caused by Hh signaling disruptions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and developmental disorders linked to Hedgehog signaling abnormalities.
How similar studies have gone: Previous research has shown promising results in targeting components of the Hedgehog signaling pathway for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Kalderon, Daniel D — Columbia Univ New York Morningside
- Study coordinator: Kalderon, Daniel D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.