Understanding how heart valves develop in babies with congenital heart disease
Prenatal valve formation in congenital heart disease
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11084505
This study is looking at how a serious heart condition called Tetralogy of Fallot affects the way heart valves form in developing babies, using chick embryos to see how unusual blood flow changes their growth, which could help doctors find better ways to diagnose and treat this condition in newborns.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11084505 on ClinicalTrials.gov |
What this research studies
This research investigates the formation of heart valves in fetuses affected by Tetralogy of Fallot (TOF), a serious congenital heart defect. By using a chick embryo model, the study aims to observe how abnormal blood flow impacts the development and remodeling of cardiac valves and arteries during critical prenatal stages. The researchers will utilize advanced imaging techniques to monitor these changes over time, providing insights into the underlying mechanisms of heart malformations. This knowledge could lead to improved strategies for early diagnosis and intervention in affected newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents whose fetuses are diagnosed with Tetralogy of Fallot or other congenital heart defects.
Not a fit: Patients with congenital heart defects unrelated to Tetralogy of Fallot may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of congenital heart defects and lead to better treatment options for affected infants.
How similar studies have performed: Previous research has shown promising results in understanding cardiac development through similar animal models, indicating potential for success in this approach.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUGONYI, SANDRA — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: RUGONYI, SANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.