Understanding how heart tissue changes during development and disease
Regulators of extracellular matrix production during cardiac development and disease
This study is looking at special heart cells that help keep the heart strong and healthy, especially after a heart attack, to find new ways to prevent or treat heart problems like heart failure, which could lead to better treatments for patients with heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11138263 on NIH RePORTER |
What this research studies
This research investigates the role of specific cells in the heart that produce extracellular matrix (ECM) proteins, which are crucial for heart structure and function. It focuses on how these cells behave during different stages of heart injury, particularly after a heart attack, and how their activity can lead to heart failure. By identifying the types of cells involved and their functions, the research aims to find new therapeutic targets to prevent or treat cardiac fibrosis, a condition that worsens heart health. Patients may benefit from insights that could lead to innovative treatments for heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced a myocardial infarction or have chronic heart conditions.
Not a fit: Patients with non-cardiac related conditions or those without a history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse heart failure caused by cardiac fibrosis.
How similar studies have performed: Previous research has shown promise in targeting ECM-producing cells for cardiac therapies, indicating potential for success in this area.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Kanisicak, Onur — Ohio State University
- Study coordinator: Kanisicak, Onur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.