Understanding how heart nerve changes lead to dangerous heart rhythms after a heart attack
Mechanisms of Cardiac TRPV1 Afferent Remodeling in Ventricular Arrhythmias
This study is looking at how a heart attack affects the nerves in your heart and how that can lead to dangerous heart rhythms, with the hope of finding better treatments for people who have these issues after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10910057 on NIH RePORTER |
What this research studies
This research investigates the changes in the heart's nerve signaling that occur after a heart attack, which can lead to dangerous heart rhythms like ventricular tachycardia and fibrillation. The study focuses on how inflammation and remodeling of nerve structures in the heart contribute to these conditions. Using a porcine model, researchers will explore the role of specific nerve signals in this process and test new approaches to potentially mitigate these harmful effects. Patients may benefit from insights that could lead to improved treatments for heart rhythm disorders following a heart attack.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are at risk for ventricular arrhythmias.
Not a fit: Patients who have not had a heart attack or do not have a history of ventricular arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent dangerous heart rhythms in patients who have suffered a heart attack.
How similar studies have performed: Previous studies have shown promising results in understanding nerve signaling in heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Ajijola, Olujimi a — University of California Los Angeles
- Study coordinator: Ajijola, Olujimi a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.