Understanding how heart muscle responds to stress in hypertrophic cardiomyopathy.
Official title: Blunting of the Myofilament Beta-Adrenergic Response in HCM: Structural-Dynamic Mechanisms
Funded at University of Arizona · NIH-10978201 · Data updated 2026-11-12
This study is looking into why people with hypertrophic cardiomyopathy (HCM) have trouble with their heart muscle relaxing, and it hopes to find new ways to help manage this condition by understanding how certain proteins in the heart work differently in these patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | August 15, 2023 |
| Project end | August 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $43,162 |
| NIH project number | 5F31HL167420-02 |
| Project ID | NIH-10978201 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypertrophic cardiomyopathy, particularly those experiencing diastolic dysfunction.
✕Less likely to help
Patients without a diagnosis of hypertrophic cardiomyopathy or those with other unrelated cardiac conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the impaired heart muscle relaxation seen in hypertrophic cardiomyopathy (HCM), a genetic heart condition affecting many individuals. The study focuses on how beta-adrenergic stimulation, which normally helps the heart relax, is altered in patients with HCM. By examining the interactions of specific proteins involved in heart muscle function, the research aims to uncover why some patients experience reduced heart relaxation. This could lead to better understanding and potential new treatments for managing HCM.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that enhance heart function and quality of life for patients with hypertrophic cardiomyopathy.
How similar studies have gone: Previous research has shown promising results in understanding cardiac function through similar protein interaction studies, indicating potential for success in this approach.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Castillo, Romi L — University of Arizona
- Study coordinator: Castillo, Romi L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.