Understanding how heart muscle power affects blood flow
Dual filament control of myocardial power and hemodynamics
This study looks at how heart muscle cells work to pump blood and how changes in these cells can affect heart health, using both lab experiments and computer models to better understand what keeps our hearts strong and efficient.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10672422 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which heart muscle fibers generate power to pump blood effectively. By using advanced biochemical and biophysical techniques, the study aims to explore how changes in the structure and function of these muscle fibers influence heart performance. The researchers will develop a computational model to predict how modifications at the cellular level can impact overall heart function and blood circulation. This approach combines laboratory experiments with theoretical modeling to provide insights into heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular conditions or those at risk of heart disease.
Not a fit: Patients with non-cardiovascular related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart conditions by improving our understanding of heart muscle function.
How similar studies have performed: Other research has shown promising results in understanding heart muscle mechanics, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Mcdonald, Kerry S — University of Missouri-Columbia
- Study coordinator: Mcdonald, Kerry S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.