Understanding how heart muscle cells form their contractile units
Mechanisms of de novo cardiac sarcomere assembly
This study is looking at how heart muscle cells are built to work properly, using heart cells made from human stem cells, to help us understand problems that can lead to heart defects and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11055378 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the assembly of sarcomeres, the essential components that enable heart muscle cells to contract effectively. By using human stem cell-derived heart cells, the team aims to explore how these structures are formed during early heart development. The study will employ advanced imaging techniques and genetic tools to identify the biological processes and factors that contribute to the formation of these critical structures. This research could provide insights into congenital heart defects and cardiomyopathies caused by errors in sarcomere assembly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart defects or those at risk of developing cardiomyopathies.
Not a fit: Patients with heart conditions unrelated to sarcomere assembly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital heart defects and cardiomyopathies.
How similar studies have performed: While the study of sarcomere assembly is well-established, the specific approach of using human pluripotent stem cells to investigate this process is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dubois, Nicole — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dubois, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.