Understanding how heart function is affected by muscle proteins in hypertrophic cardiomyopathy.
Modulation of heart function by Muscle LIM protein-mediated mechanotransduction
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10865135
This study is looking at familial hypertrophic cardiomyopathy (HCM), a heart condition that runs in families, by using special heart cells made from patients' own stem cells to see how different forces affect heart function, with the goal of finding new ways to help treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10865135 on ClinicalTrials.gov |
What this research studies
This research investigates familial hypertrophic cardiomyopathy (HCM), a common inherited heart condition caused by mutations in proteins that control heart muscle contraction. The team uses patient-specific stem cells to create heart cells and engineered heart tissues, allowing them to study how mechanical forces affect heart function at both cellular and tissue levels. By combining these models with computational simulations and gene editing techniques, they aim to uncover new pathways that contribute to the disease and explore potential therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with familial hypertrophic cardiomyopathy, particularly those with specific genetic mutations affecting heart muscle proteins.
Not a fit: Patients without a diagnosis of familial hypertrophic cardiomyopathy or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of serious complications in patients with hypertrophic cardiomyopathy.
How similar studies have performed: Previous research has shown promise in using engineered heart tissues and stem cell models to study cardiac diseases, indicating that this approach has potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QYANG, YIBING — YALE UNIVERSITY
- Study coordinator: QYANG, YIBING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.