Understanding how heart failure patients without certain ECG patterns respond to therapy
Factors Associated with Response to Cardiac Resynchronization Therapy in Heart Failure Patients with Non-LBBB ECG Pattern
This study is looking at how well a special heart treatment works for people with heart failure who don’t have a specific heart rhythm issue, to help figure out who might benefit the most from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10877746 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of cardiac resynchronization therapy with a defibrillator in heart failure patients who do not have left bundle branch block (non-LBBB) patterns on their ECG. The study aims to identify which patients may benefit from this therapy by analyzing their echocardiography responses and utilizing advanced statistical methods, including machine learning. By focusing on this specific patient group, the research seeks to improve patient selection for this costly treatment, potentially leading to better health outcomes. Participants will be monitored to validate predictors of therapy response.
Who could benefit from this research
Good fit: Ideal candidates for this research are heart failure patients with non-LBBB ECG patterns who are being considered for cardiac resynchronization therapy.
Not a fit: Patients with left bundle branch block (LBBB) or those who do not have heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for heart failure patients, reducing unnecessary procedures and improving patient outcomes.
How similar studies have performed: Previous studies have shown varying responses to cardiac resynchronization therapy in different patient populations, but this specific focus on non-LBBB patients is relatively novel.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Valentina Kutyifa, Valentina Kutyifa Valentina Kutyifa — University of Rochester
- Study coordinator: Valentina Kutyifa, Valentina Kutyifa Valentina Kutyifa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.