Understanding how heart failure patients with a specific ECG pattern respond to a special pacemaker
Factors Associated with Response to Cardiac Resynchronization Therapy in Heart Failure Patients with Non-LBBB ECG Pattern
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11129771
This research looks for better ways to identify heart failure patients with a non-LBBB ECG pattern who will benefit most from a special pacemaker called Cardiac Resynchronization Therapy with a defibrillator (CRT-D).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11129771 on ClinicalTrials.gov |
What this research studies
Many people with heart failure benefit from a special pacemaker called CRT-D, which helps their heart beat more effectively. However, some patients, especially those without a specific ECG pattern called Left Bundle Branch Block (non-LBBB), may not get the full benefit from this device. This project aims to find clear signs, using ECG and echocardiography, that can predict which non-LBBB heart failure patients will respond well to CRT-D. By using advanced data analysis, including machine learning, we hope to improve how doctors choose patients for this important therapy. This could help ensure that patients receive the most effective treatment for their condition.
Who could benefit from this research
Good fit: Ideal candidates are heart failure patients with a wide QRS and low ejection fraction who have a non-LBBB ECG pattern and are considering or have received Cardiac Resynchronization Therapy with a defibrillator (CRT-D).
Not a fit: Patients who do not have heart failure or who have a clear Left Bundle Branch Block (LBBB) ECG pattern may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors better select heart failure patients with a non-LBBB ECG pattern who are most likely to benefit from CRT-D, avoiding unnecessary procedures for those unlikely to respond.
How similar studies have performed: Previous research by this team has identified some predictors of response in non-LBBB patients, but this new project aims to prospectively validate and discover additional predictors using novel methods.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUTYIFA, VALENTINA — UNIVERSITY OF ROCHESTER
- Study coordinator: KUTYIFA, VALENTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bundle Branch disorder