Understanding how heart energy changes in heart disease
Energetic State and Metabolic Remodeling in Cardiac Hypertrophy and Failure
This study is looking at how heart problems like high blood pressure and aortic valve narrowing affect the heart's energy production, and it aims to see if boosting a specific enzyme can help improve heart function for people with heart enlargement.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10879108 on NIH RePORTER |
What this research studies
This research investigates how the heart's energy production and metabolism change in response to conditions like high blood pressure and aortic valve stenosis, which can lead to heart enlargement and failure. The study focuses on the role of a specific enzyme complex, F1Fo-ATP synthase, which is crucial for generating energy in heart cells. By using gene therapy to enhance the function of this enzyme, the researchers aim to restore normal heart function in patients with heart hypertrophy. This approach could provide insights into new treatments for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cardiac hypertrophy or heart failure, particularly those with conditions like hypertension or aortic valve stenosis.
Not a fit: Patients without heart disease or those who do not have conditions affecting heart function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Previous studies have shown promising results in enhancing heart function through gene therapy targeting metabolic pathways, indicating potential success for this approach.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Yang, Qinglin — Lsu Health Sciences Center
- Study coordinator: Yang, Qinglin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.