Understanding how heart defects affect brain development in children.
Oligo-Vascular Crosstalk in the Developing Brain: Implications For White Matter Injury In Congenital Heart Disease
This study is looking at how congenital heart disease can affect brain development in young children, especially how issues with blood flow and oxygen might lead to problems in the brain, and it hopes to find ways to help kids with these heart conditions have better outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10877795 on NIH RePORTER |
What this research studies
This research investigates the impact of congenital heart disease (CHD) on brain development, particularly focusing on how poor blood flow and oxygen delivery can lead to white matter injuries in young children. By using a novel mouse model that simulates human heart defects, the study aims to uncover the relationship between heart structure and brain vascularization. The findings could help identify mechanisms behind neurodevelopmental issues like cerebral palsy in children with CHD, ultimately aiming to improve outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with congenital heart disease.
Not a fit: Patients without congenital heart disease or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and interventions for neurodevelopmental challenges in children with congenital heart disease.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between heart defects and brain development, indicating that this approach has potential for significant insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Chavali, Manideep — Oregon Health & Science University
- Study coordinator: Chavali, Manideep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.