Understanding how heart channels are regulated and finding new treatments for heart issues
Investigating Cardiac Ion Channels by Novel Methods
This study is looking at how certain channels in the heart that help control calcium levels work, especially when the heart is under stress, using specially modified mice to find new ways to help treat heart problems like heart failure and irregular heartbeats.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10840943 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate calcium channels in the heart, which are crucial for heart function. By studying genetically modified mice, the researchers aim to uncover how these channels are influenced by various signaling pathways, particularly during stress responses. The approach involves advanced techniques like multiplexed proteomics to analyze proteins associated with these channels, potentially leading to new therapeutic targets for conditions like heart failure and arrhythmias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions such as heart failure or arrhythmias.
Not a fit: Patients without any cardiac issues or those who do not respond to β-adrenergic therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of arrhythmias in patients.
How similar studies have performed: Previous research has shown promise in understanding cardiac ion channels, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Marx, Steven O — Columbia University Health Sciences
- Study coordinator: Marx, Steven O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.