Understanding how heart cells respond to injury and fibrosis
Regulators of Myofibroblast State Stability & Fibrotic Responsiveness of the Heart
This study is looking at special heart cells called myofibroblasts that help heal the heart after injuries, to see how they switch between being active and inactive, which could help us find better treatments for heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10852861 on NIH RePORTER |
What this research studies
This research investigates the role of myofibroblasts, a type of heart cell that contributes to scar tissue formation, in the context of heart disease. It aims to understand how these cells transition between active and inactive states, particularly after heart injuries. By examining the mechanisms that regulate these transitions, the study seeks to uncover how myofibroblasts can either promote healing or contribute to worsening heart conditions. The research employs experimental techniques to manipulate specific cellular pathways, which may lead to new therapeutic strategies for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with existing heart conditions that may involve fibrosis or scarring.
Not a fit: Patients with acute heart injuries that do not involve fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse heart fibrosis, improving outcomes for patients with heart disease.
How similar studies have performed: Previous research in other organs has shown promising results in understanding myofibroblast behavior, but this specific approach in the heart is novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Davis, Jennifer Michelle — University of Washington
- Study coordinator: Davis, Jennifer Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.