Understanding how heart cells respond to immune signals
Official title: YAP and IRF2BP2 regulation of cardiomyocyte innate immune responses
Funded at Masonic Medical Research Laboratory, INC · NIH-10989953 · Data updated 2026-11-12
This study is looking at how heart muscle cells respond to stress and injury, with the goal of finding new ways to help protect your heart and improve its health, especially if you have heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Masonic Medical Research Laboratory, INC NIH-funded |
| Lab location | 1 site (Utica, United States) |
| Project start | December 15, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $573,667 |
| NIH project number | 5R01HL146810-04 |
| Project ID | NIH-10989953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced heart-related conditions, such as myocardial infarction or heart failure.
✕Less likely to help
Patients with non-cardiac conditions or those under 21 years old may not receive benefits from this research.
What this research studies
This research investigates the innate immune responses of cardiomyocytes, the heart's muscle cells, which are crucial for heart function. It aims to uncover the molecular mechanisms that regulate these immune responses, particularly in the context of heart diseases like heart failure. By examining how certain proteins, such as YAP and IRF2BP2, influence the immune signaling pathways in cardiomyocytes, the research seeks to identify potential therapeutic targets for improving heart health. Patients may benefit from insights gained about how to protect heart cells from damage during stress or injury.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart cell resilience and improve recovery from heart injuries.
How similar studies have gone: Other research has shown promising results in understanding immune responses in heart cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Masonic Medical Research Laboratory, INC
Utica, United States Active
Researchers
- Principal investigator: Lin, Zhiqiang — Masonic Medical Research Laboratory, INC
- Study coordinator: Lin, Zhiqiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.