Understanding how heart cells produce collagen after heart injury
Role of the PEP cycle in cardiac fibrosis
This study looks at how heart cells called fibroblasts change after a heart attack to help heal by making collagen, and it aims to find ways to improve heart recovery by understanding the changes these cells go through.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-10989895 on NIH RePORTER |
What this research studies
This research investigates how fibroblasts, a type of cell in the heart, change their behavior after a heart attack to produce large amounts of collagen, which is crucial for healing. The study focuses on the metabolic changes that occur in these cells to support their increased collagen production. By examining the biochemical pathways involved, researchers aim to identify potential targets for therapies that could improve heart healing and function after injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are recovering from heart injury.
Not a fit: Patients who have not had a heart attack or those with advanced heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart recovery and reduce complications after heart attacks.
How similar studies have performed: Previous studies have shown that understanding metabolic changes in heart cells can lead to significant advancements in cardiac care, suggesting this approach has potential for success.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Hill, Bradford Guy — University of Louisville
- Study coordinator: Hill, Bradford Guy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.