Understanding how heart cells mature from birth to adulthood
Functional dissection of the regulatory network that governs cardiomyocyte maturation
['FUNDING_OTHER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10896471
This study is looking at how heart cells grow and change from when we're babies to adults, and it's especially for people with congenital heart defects, as understanding these changes could help improve treatments for heart problems later on.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10896471 on ClinicalTrials.gov |
What this research studies
This research investigates the complex changes that heart muscle cells, known as cardiomyocytes, undergo as they mature from infancy to adulthood. By utilizing advanced techniques like CRISPR screens, the study aims to identify the regulatory networks that control this maturation process. Understanding these mechanisms is crucial for improving cardiac regenerative medicine, particularly for patients with congenital heart defects. The research focuses on how disruptions in this maturation can lead to heart failure later in life.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital heart defects or those interested in cardiac regenerative therapies.
Not a fit: Patients with fully developed and healthy cardiac function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for heart diseases, particularly for patients with congenital heart defects.
How similar studies have performed: Other research has shown promising results in understanding cardiac cell maturation, but this specific approach using CRISPR technology is relatively novel.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VANDUSEN, NATHAN JAMES — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: VANDUSEN, NATHAN JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.