Understanding how heart cells grow and regenerate after damage
Official title: Mechanotransduction Mechanisms of Cardiac Growth and Regeneration
Funded at Rhode Island Hospital · NIH-11047946 · Data updated 2026-11-12
This study is looking at how heart cells grow and heal after a heart attack, with the hope of finding new ways to help people with heart failure feel better and recover more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $601,507 |
| NIH project number | 1R01HL173366-01A1 |
| Project ID | NIH-11047946 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have experienced heart damage, such as from a heart attack.
✕Less likely to help
Patients with non-cardiac related health issues or those who have not experienced heart damage may not benefit from this research.
What this research studies
This research investigates the molecular pathways that control the growth and regeneration of heart cells, particularly after a heart attack. It focuses on how changes in cell adhesion and the cytoskeleton influence the ability of heart cells to proliferate and recover. By studying these mechanisms, the research aims to identify new therapeutic targets that could enhance heart repair and function. Patients may benefit from insights gained in this research, which could lead to innovative treatments for heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help regenerate heart tissue and improve recovery after heart attacks.
How similar studies have gone: Previous research has shown promising results in understanding heart cell proliferation mechanisms, suggesting potential for success in this area.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Radice, Glenn Lawrence — Rhode Island Hospital
- Study coordinator: Radice, Glenn Lawrence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.