Understanding how heart cells grow and divide in mammals.
Neurohumoral Interactions Coordinating Mammalian Cardiomyocyte Size and Proliferation
This study looks at how heart muscle cells grow and divide differently in babies compared to adults, and it explores how certain hormones might help the heart heal better after an injury, which could lead to new ways to treat heart failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Jose State University NIH-funded |
| Lab location | 1 site (San Jose, United States) |
| Project ID | NIH-10876957 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the growth and division of heart muscle cells, particularly focusing on how these processes differ between newborns and adults. By examining the effects of thyroid hormone and adrenergic receptor signaling, the study aims to uncover how these factors influence heart regeneration after injury. The goal is to identify physiological triggers that could enhance the heart's ability to regenerate, potentially leading to new treatments for heart failure. Patients may benefit from insights gained about improving heart repair mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include adults with a history of heart failure or ischemic injury.
Not a fit: Patients with congenital heart defects or those who are not experiencing heart failure may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart regeneration in adults after heart attacks.
How similar studies have performed: Previous research has shown promising results in understanding heart regeneration in neonatal models, suggesting potential for breakthroughs in adult heart repair.
Where this research is happening
San Jose, United States
- San Jose State University — San Jose, United States (Active)
Researchers
- Principal investigator: Payumo, Alexander Y — San Jose State University
- Study coordinator: Payumo, Alexander Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.