Understanding How Heart Cells Generate Electrical Rhythms
Translational Control of Cardiac Excitability
This research explores how heart cells precisely build the proteins that create the heart's regular electrical rhythm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11002016 on NIH RePORTER |
What this research studies
Our hearts beat regularly thanks to a precise arrangement of proteins called ion channels within heart cells. This research aims to understand how these cells coordinate the creation of these vital proteins. We believe that groups of genetic instructions work together to build these proteins, which then assemble into tiny structures that control the heart's electrical activity. By studying these structures in both developing and adult heart cells, we hope to uncover new ways the heart manages its rhythm, which could lead to new treatments for heart conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies stemming from it may seek individuals with heart rhythm conditions.
Not a fit: Patients seeking immediate treatment options for existing heart conditions will not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new targets for developing medications or therapies to treat heart rhythm disorders.
How similar studies have performed: This research proposes a novel approach to understanding how ion channels are assembled in the heart, building on recent progress in the field.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Robertson, Gail a — University of Wisconsin-Madison
- Study coordinator: Robertson, Gail a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.