Understanding how heart cells develop from specific progenitor cells
Official title: Mechanisms of Juxta-Cardiac Field Progenitors
Funded at University of California, San Diego · NIH-10903408 · Data updated 2026-11-12
This study is exploring how different types of heart cells are created from special cells during heart development, which could help us understand heart problems better and lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $763,930 |
| NIH project number | 1R01HL174023-01 |
| Project ID | NIH-10903408 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with congenital heart disease or those interested in the genetic basis of heart conditions.
✕Less likely to help
Patients with acquired heart conditions unrelated to developmental mechanisms may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which diverse cardiac cell types are formed from Juxta-Cardiac Field progenitors during heart development. By employing a combination of experimental and computational methods, the study aims to identify the genetic and regulatory networks that guide the differentiation of these progenitors into specific heart cell types. The findings could enhance our understanding of congenital heart disease and inform the development of new therapies for heart conditions. Patients may benefit from insights into the origins of their heart conditions and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for congenital heart disease and better understanding of heart development.
How similar studies have gone: Other research has shown promise in understanding cardiac development through similar genetic and regulatory approaches, suggesting potential for success in this area.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Chi, Neil C — University of California, San Diego
- Study coordinator: Chi, Neil C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.