Understanding how heart cells develop from specific progenitor cells
Mechanisms of Juxta-Cardiac Field Progenitors
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10903408
This study is exploring how different types of heart cells are created from special cells during heart development, which could help us understand heart problems better and lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10903408 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which diverse cardiac cell types are formed from Juxta-Cardiac Field progenitors during heart development. By employing a combination of experimental and computational methods, the study aims to identify the genetic and regulatory networks that guide the differentiation of these progenitors into specific heart cell types. The findings could enhance our understanding of congenital heart disease and inform the development of new therapies for heart conditions. Patients may benefit from insights into the origins of their heart conditions and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with congenital heart disease or those interested in the genetic basis of heart conditions.
Not a fit: Patients with acquired heart conditions unrelated to developmental mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for congenital heart disease and better understanding of heart development.
How similar studies have performed: Other research has shown promise in understanding cardiac development through similar genetic and regulatory approaches, suggesting potential for success in this area.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHI, NEIL C — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CHI, NEIL C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.