Understanding how heart cells communicate to grow and heal.
Explore the roles of intercellular communication in cardiomyocyte proliferation and renewal.
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11005201
This study is looking at how heart cells grow and heal, especially when there isn't enough oxygen, to find new ways to help the heart recover after injuries like a heart attack.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11005201 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind heart cell (cardiomyocyte) growth and renewal, particularly focusing on how communication between heart cells and endothelial cells is influenced by oxygen levels. The study aims to uncover how low oxygen conditions can stimulate heart cell proliferation, which is crucial for recovery after heart injuries like myocardial infarction. By exploring the role of specific proteins that sense oxygen, the research seeks to identify new therapeutic strategies to enhance heart cell regeneration and combat heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart conditions, particularly those experiencing heart failure or recovery from heart injuries.
Not a fit: Patients with stable heart conditions who do not exhibit signs of heart failure or injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote heart cell regeneration, potentially improving outcomes for patients with heart failure.
How similar studies have performed: Previous studies have shown promise in understanding heart cell proliferation through similar mechanisms, indicating a potential for success in this area of research.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIE, LIANG — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: XIE, LIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.