Understanding how heart cells communicate in a specific type of heart disease
Deciphering the Endothelial Cell-Cardiomyocyte Crosstalk in LMNA Cardiomyopathy
This study is looking at how heart cells and blood vessel cells talk to each other in people with a specific type of heart disease caused by a gene mutation, and it hopes to find out if certain treatments can help improve their function and lead to better care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11134461 on NIH RePORTER |
What this research studies
This research investigates the communication between endothelial cells and cardiomyocytes in patients with dilated cardiomyopathy caused by mutations in the LMNA gene. By using induced pluripotent stem cells to create endothelial cells and cardiomyocytes, the study aims to uncover the molecular mechanisms behind this heart condition. The researchers will explore how treatments, such as certain statins, can improve endothelial dysfunction and positively influence heart cell function. This approach may reveal new therapeutic targets for patients suffering from this severe heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with LMNA gene mutations.
Not a fit: Patients with dilated cardiomyopathy not caused by LMNA mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function in patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding endothelial dysfunction in heart diseases, indicating potential for success in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Sayed, Nazish — Stanford University
- Study coordinator: Sayed, Nazish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.