Understanding how heart cells communicate and contract in relation to arrhythmias.
Atrial Excitation-Contraction Coupling, Calcium Signaling and Electro-Mechanical Alternans
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-10864963
This study looks at how calcium signals in heart cells affect heart function and can lead to irregular heartbeats, like atrial fibrillation, with the goal of finding better treatments for people with heart rhythm problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10864963 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of excitation-contraction coupling in atrial heart cells, focusing on how calcium signaling affects heart function and arrhythmias like atrial fibrillation. The study examines the unique features of calcium release from different types of sarcoplasmic reticulum in these cells and how disturbances in this process can lead to irregular heartbeats. By exploring the relationship between electrical signals and calcium dynamics, the research aims to develop a better understanding of the factors contributing to cardiac alternans, which is linked to arrhythmias. This could lead to new insights into potential treatments for patients with heart rhythm disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with atrial fibrillation or other types of cardiac arrhythmias.
Not a fit: Patients without any history of heart rhythm disorders or those with non-cardiac related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from atrial fibrillation and other cardiac arrhythmias.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in cardiac cells, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BANACH, KATHRIN — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: BANACH, KATHRIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.