Understanding how heart cells change in response to diseases
Official title: Mechanisms of Purkinje Cell Remodeling
Funded at New York University School of Medicine · NIH-11111457 · Data updated 2026-11-12
This study is looking at how certain health issues like high blood pressure, diabetes, and obesity change important heart cells, with the goal of finding new ways to help improve heart function and treat heart rhythm problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $847,164 |
| NIH project number | 5R01HL171118-02 |
| Project ID | NIH-11111457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from cardiovascular diseases related to hypertension, diabetes, or obesity.
✕Less likely to help
Patients with congenital heart defects unrelated to Purkinje cell function may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the remodeling of Purkinje cells, which are crucial for the heart's electrical conduction system. By utilizing advanced genetic tools and innovative animal models, the study aims to uncover how conditions like hypertension, diabetes, and obesity affect these cells and contribute to heart diseases. The researchers will analyze gene expression and signaling pathways to identify potential therapeutic targets for improving heart function. Patients may benefit from insights that could lead to new treatments for arrhythmias and other cardiac disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce the risk of arrhythmias in patients with common cardiovascular conditions.
How similar studies have gone: Previous research has successfully identified genetic pathways in heart diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Fishman, Glenn I — New York University School of Medicine
- Study coordinator: Fishman, Glenn I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.