Understanding how heart cells change during stress and how to improve heart function.
Integrating Transcriptome Reprogramming Into Cardiac Plasticity Regulatory Mechanisms
This study is looking at how heart cells change from a baby-like state to a more mature state when they're under stress, focusing on a protein called MBNL1 that helps with this process, and it hopes to find ways to improve heart health and recovery for people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11052533 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which heart muscle cells transition from a fetal state to an adult state under stress conditions. It focuses on a specific protein, MBNL1, which plays a crucial role in regulating these transitions and how they affect heart performance and regeneration. By analyzing gene expression in cardiac myocytes, the study aims to identify ways to enhance heart function and resilience against stress, potentially leading to new treatments for heart failure. Patients may benefit from insights gained about improving cardiac health and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure or related cardiac conditions.
Not a fit: Patients with non-cardiac conditions or those not experiencing heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart function and regeneration in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding cardiac cell reprogramming, suggesting that this approach may lead to significant advancements in heart failure treatment.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Davis, Jennifer Michelle — University of Washington
- Study coordinator: Davis, Jennifer Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.