Understanding how heart cells can grow and regenerate
Computational and Experimental Modeling of Cardiomyocyte Proliferation
This study is looking into why heart cells struggle to heal after an injury, which can lead to heart failure, and it's for anyone interested in new ways to help the heart grow and repair itself better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11003685 on NIH RePORTER |
What this research studies
This research investigates the limited ability of heart cells, known as cardiomyocytes, to regenerate after injury, which is a major cause of heart failure. By using both computational models and experimental methods, the team aims to identify and understand the molecular regulators that control cardiomyocyte proliferation. The study includes validating these regulators in various models, including human stem cell-derived cardiomyocytes and mouse models, to develop potential therapies that could stimulate heart cell growth and repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure, particularly adults under 21 years old.
Not a fit: Patients with non-cardiac related conditions or those who do not have heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the regeneration of heart cells, potentially improving outcomes for patients with heart failure.
How similar studies have performed: Other research has shown promise in understanding cardiomyocyte proliferation, but this approach integrates novel computational modeling with experimental validation, making it a potentially groundbreaking effort.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Saucerman, Jeffrey J. — University of Virginia
- Study coordinator: Saucerman, Jeffrey J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.