Understanding how heart cells and blood vessel cells communicate in a specific heart condition.
Deciphering the Endothelial Cell-Cardiomyocyte Crosstalk in LMNA Cardiomyopathy
This study is looking at how heart and blood vessel cells talk to each other in people with a specific heart condition caused by a gene mutation, and it hopes to find new ways to improve heart health using certain medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10901940 on NIH RePORTER |
What this research studies
This research investigates the communication between endothelial cells (which line blood vessels) and cardiomyocytes (heart muscle cells) in patients with dilated cardiomyopathy caused by mutations in the LMNA gene. By using induced pluripotent stem cells derived from patients, the study aims to uncover the molecular mechanisms behind this condition and how endothelial dysfunction affects heart function. The researchers will explore potential treatments that could improve cell communication and heart health, particularly through the use of certain statins. This work could lead to new insights into heart disease and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with mutations in the LMNA gene.
Not a fit: Patients without dilated cardiomyopathy or those whose heart conditions are unrelated to endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with dilated cardiomyopathy, potentially enhancing heart function and reducing the need for heart transplants.
How similar studies have performed: Previous research has shown promising results in understanding endothelial dysfunction in heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Sayed, Nazish — Stanford University
- Study coordinator: Sayed, Nazish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.