Understanding how heart cells adapt to changes in their environment
Uncovering The Mechanogenomic Basis For Cardiac Plasticity
This study is looking at how certain heart cells and their helpers, called fibroblasts, work together in people with dilated cardiomyopathy, a common cause of heart failure, to find new ways to improve heart health and treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11128760 on NIH RePORTER |
What this research studies
This research investigates the role of cardiac fibroblasts in dilated cardiomyopathy (DCM), a leading cause of heart failure. It focuses on how inherited mutations in heart muscle cells affect their function and how the surrounding fibroblasts contribute to heart tissue changes. By studying these interactions, the research aims to identify new therapeutic approaches that target both heart muscle cells and fibroblasts to improve heart health. Patients may benefit from insights that could lead to more effective treatments for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with inherited genetic mutations affecting heart muscle function.
Not a fit: Patients without dilated cardiomyopathy or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and outcomes for patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in targeting cardiac fibroblasts for improving heart function, indicating that this approach may be effective.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Davis, Jennifer Michelle — University of Washington
- Study coordinator: Davis, Jennifer Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.