Understanding how heart and muscle cells manage energy and oxygen transport
Official title: Mitochondrial succinyl CoA management at the intersection of heme and ketone metabolism
Funded at Duke University · NIH-10997112 · Data updated 2026-11-12
This study looks at how heart and muscle cells use a key substance called succinyl-CoA to produce energy and transport oxygen, especially in people with heart failure, to find better ways to improve their metabolism and overall health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $73,408 |
| NIH project number | 1F32HL176113-01 |
| Project ID | NIH-10997112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart failure or those experiencing cardiac dysfunction.
✕Less likely to help
Patients without any cardiac conditions or metabolic disorders may not receive direct benefits from this research.
What this research studies
This research investigates how heart and skeletal muscle cells handle a crucial metabolite called succinyl-CoA, which plays a key role in energy production and oxygen transport. The study focuses on the balance between heme synthesis, which is vital for oxygen delivery, and ketone oxidation, an important energy source during fasting. By examining how these processes are regulated, especially in the context of heart failure, the research aims to uncover potential metabolic dysfunctions that could lead to better treatment strategies. Patients may benefit from insights into how their heart and muscle metabolism can be optimized.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart failure by enhancing our understanding of energy and oxygen metabolism in heart and muscle cells.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways in heart failure, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Poss, Annelise — Duke University
- Study coordinator: Poss, Annelise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.