Understanding how healthy cells interact with cancerous blood cells in myeloproliferative neoplasms
Cell Competition in Myeloproliferative Neoplasms
This study is looking at how healthy blood cells can help control the growth of cancerous blood cells in patients with myeloproliferative neoplasms (MPNs), with the hope of finding better treatments for those affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10880317 on NIH RePORTER |
What this research studies
This research investigates the dynamics between healthy and mutant blood stem cells in patients with myeloproliferative neoplasms (MPNs), a type of blood cancer. By using laboratory techniques such as co-culture assays and transplantation models, the study aims to understand how healthy cells can inhibit the growth of cancerous cells. The goal is to uncover mechanisms that could lead to better treatments and outcomes for patients with MPNs, particularly those at risk of developing acute leukemia. Patients may be monitored over time to assess changes in their blood cell populations and responses to potential therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with myeloproliferative neoplasms, particularly those with the JAK2V617F mutation.
Not a fit: Patients with other types of blood cancers or those without myeloproliferative neoplasms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the body's ability to control or eliminate cancerous blood cells.
How similar studies have performed: Previous research has shown that interactions between healthy and cancerous cells can influence disease progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Zhan, Huichun — State University New York Stony Brook
- Study coordinator: Zhan, Huichun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.