Understanding how head and neck cancer responds to radiation and immunotherapy
P3: Molecular Mechanisms Underlying Therapy Response to Radiation and Immune Checkpoint BlockadeýSUBAWARD
This study is looking at how certain biological factors affect how patients with head and neck cancer respond to radiation and immune treatments, with the hope of making these therapies work better and cause less harm to healthy cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10896486 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that influence how head and neck squamous cell carcinoma (HNSCC) patients respond to radiation therapy and immune checkpoint blockade treatments. By analyzing biospecimens and data from patients undergoing these therapies, the study aims to identify factors that contribute to treatment resistance and recurrence. The goal is to enhance the effectiveness of radiation therapy while minimizing damage to healthy tissues. This research will utilize advanced techniques, including CRISPR-based screens, to explore the DNA damage response in cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locoregionally recurrent head and neck squamous cell carcinoma who are undergoing radiation therapy combined with chemotherapy or immunotherapy.
Not a fit: Patients with early-stage head and neck cancer or those not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for head and neck cancer, potentially increasing survival rates and reducing recurrence.
How similar studies have performed: Previous research has shown promising results in understanding treatment responses in other cancers using similar biological and molecular approaches.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Yu, David Sung-Wen — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Yu, David Sung-Wen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.