Understanding how HDAC6 affects immune cell responses in sepsis
HDAC6 regulation of myeloid cell responses in sepsis
['FUNDING_R01'] · UNIVERSITY OF KENTUCKY · NIH-10896154
This study is looking at a protein called HDAC6 to see how it affects immune cells during sepsis, a serious infection-related condition, and whether blocking this protein can help these cells work better and improve survival in people with sepsis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-10896154 on ClinicalTrials.gov |
What this research studies
This research investigates the role of HDAC6, a protein that regulates various cellular responses, in the context of sepsis, a severe condition caused by infections. The study aims to understand how HDAC6 influences myeloid cell responses, which are crucial for immune function and can become dysfunctional during sepsis. By using mouse models, the researchers will explore whether inhibiting HDAC6 can improve the survival and function of these immune cells in sepsis. The findings could lead to new therapeutic strategies for managing sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently experiencing sepsis.
Not a fit: Patients with non-infectious conditions or those not at risk for sepsis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis, potentially reducing mortality rates and enhancing recovery for patients.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in immune cells, suggesting potential for success in this approach.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FU, JIAN — UNIVERSITY OF KENTUCKY
- Study coordinator: FU, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.