Understanding how HDAC3 affects Langerhans cell histiocytosis
Official title: Epigenetic Regulation of Langerhans Cell Histiocytosis Pathophysiology and Microenvironment by HDAC3
Funded at Wayne State University · NIH-11030234 · Data updated 2026-11-12
This study is looking at how a protein called HDAC3 affects Langerhans cell histiocytosis (LCH), a rare inflammatory condition, to find better and safer treatment options for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | March 1, 2024 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $39,622 |
| NIH project number | 5F30GM149139-02 |
| Project ID | NIH-11030234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Langerhans cell histiocytosis, particularly those experiencing severe or recurrent forms of the disease.
✕Less likely to help
Patients with other types of histiocytosis or those without a diagnosis of LCH may not benefit from this research.
What this research studies
This research investigates the role of HDAC3 in the development and behavior of Langerhans cell histiocytosis (LCH), a rare inflammatory condition. By examining how HDAC3 influences myeloid cells, the study aims to uncover new therapeutic strategies that could improve treatment outcomes for patients with LCH. The approach involves analyzing the microenvironment of LCH and how it contributes to the disease's persistence and severity. Patients may benefit from insights that could lead to more effective and less toxic treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve treatment outcomes for patients with LCH.
How similar studies have gone: While research on HDAC3 is ongoing, this specific approach to targeting LCH is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Dimitrion, Peter — Wayne State University
- Study coordinator: Dimitrion, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.