Understanding how HCV exosomes affect liver disease and fibrosis
Role of HCV exosomes in intercellular communication
This study is looking at how tiny particles called exosomes from liver cells infected with hepatitis C might contribute to liver problems like scarring and cancer, and it aims to find ways to help protect the liver from damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10798128 on NIH RePORTER |
What this research studies
This research investigates the role of exosomes released from hepatitis C virus (HCV)-infected liver cells in promoting liver disease, particularly fibrosis and hepatocellular carcinoma. By studying how these exosomes communicate with other liver cells, the researchers aim to uncover the mechanisms that lead to liver damage and disease progression. The project involves both laboratory experiments and animal models to identify the molecular processes involved and to explore potential therapeutic strategies to mitigate liver fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic hepatitis C infection who are at risk of developing liver fibrosis or hepatocellular carcinoma.
Not a fit: Patients without hepatitis C infection or those with advanced liver disease unrelated to HCV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce liver fibrosis in patients with chronic HCV infection.
How similar studies have performed: Previous research has shown promising results in understanding the role of exosomes in liver disease, suggesting that this approach may yield valuable insights and therapeutic options.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Hahn, Young S. — University of Virginia
- Study coordinator: Hahn, Young S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.