Understanding how HCN channels work in the heart and brain
Structural Studies of HCN Channels in Health and Disease
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10647829
This study is looking at how certain proteins in your heart and brain work to control their rhythms, which could help us find better ways to treat heart issues and seizures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10647829 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that regulate HCN channels, which play a crucial role in controlling heart rhythms and brain activity. By using advanced techniques like cryo-electron microscopy, the team aims to explore how different parts of the HCN protein interact and affect its function. The study focuses on the structural differences between various HCN isoforms and how these differences influence their gating properties. This knowledge could lead to better understanding and treatment of conditions like arrhythmias and epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac arrhythmias or epilepsy, as they may benefit from advancements in understanding HCN channel function.
Not a fit: Patients with conditions unrelated to heart or brain function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart and brain disorders related to HCN channel dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding ion channels, making this approach a continuation of successful investigations in the field.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIEGELBAUM, STEVEN A — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: SIEGELBAUM, STEVEN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.