Understanding how HCMV behaves during dormancy and reactivation
HCMV GPCR functions during latency and reactivation
This study looks at how the human cytomegalovirus (HCMV) stays hidden in the body and what makes it wake up, especially in people with weak immune systems, to help find ways to prevent related health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11030738 on NIH RePORTER |
What this research studies
This research investigates the behavior of the human cytomegalovirus (HCMV) during its dormant phase and when it reactivates, particularly focusing on specific viral receptors that influence these processes. The study aims to uncover how HCMV manages to remain latent in the body and what triggers its reactivation, which can lead to serious health issues, especially in individuals with weakened immune systems. By examining the signaling pathways involved, the research seeks to provide insights that could help in developing strategies to prevent HCMV-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with weakened immune systems, such as organ transplant recipients or those with certain chronic illnesses.
Not a fit: Patients who are immunocompetent and have no history of HCMV infection are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing severe diseases caused by HCMV reactivation, particularly in vulnerable populations.
How similar studies have performed: Previous research has shown promising results in understanding viral latency and reactivation, indicating that this approach has potential for significant advancements.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: O'connor, Christine M — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: O'connor, Christine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.