Understanding how harmful chemicals affect lung health using advanced technology.
Official title: Characterizing chemical threat agent exposures using a lung-on-a-chip platform and multi-omic analysis of common pathophysiological mechanisms
Funded at Wake Forest University Health Sciences · NIH-10913409 · Data updated 2026-11-12
This study is looking at how harmful chemicals affect lung health using a special 3D model that acts like human lungs, with the goal of finding better ways to protect and treat people who have lung injuries from these substances.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | August 25, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $310,000 |
| NIH project number | 5R01ES034416-02 |
| Project ID | NIH-10913409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to harmful chemicals or are at risk of such exposures, particularly those in high-risk occupations or environments.
✕Less likely to help
Patients who have not been exposed to any toxic chemicals or who do not have lung-related health issues may not benefit from this research.
What this research studies
This research investigates the effects of highly toxic chemicals on lung health by utilizing a 3D lung model that mimics human airway tissues. The team will expose these models to various harmful substances to observe how they cause injury and to identify potential treatments. By analyzing the biological responses at a molecular level, the research aims to uncover new pathways of toxicity and develop medical countermeasures to protect against these threats. Patients may benefit from improved understanding and treatment options for lung injuries caused by chemical exposures.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for lung injuries caused by toxic chemical exposures.
How similar studies have gone: Other research has shown promise in using similar 3D lung models to study toxic exposures, indicating that this approach could yield valuable insights.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Murphy, Sean Vincent — Wake Forest University Health Sciences
- Study coordinator: Murphy, Sean Vincent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.