Understanding how hantavirus proteins assemble and interact with host cells
Official title: Host-virus interactions in hantavirus glycoprotein assembly
Funded at Albert Einstein College of Medicine · NIH-11125015 · Data updated 2026-11-12
This study is looking at how hantavirus proteins work with our cells to help the virus infect us and avoid our immune system, with the hope of finding new ways to create treatments for hantavirus infections that currently have no approved medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 7, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $681,755 |
| NIH project number | 1R56AI175292-01A1 |
| Project ID | NIH-11125015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to hantaviruses or are at risk of infection, particularly those living in areas where these viruses are prevalent.
✕Less likely to help
Patients who are not at risk of hantavirus infection or those with existing antiviral treatments may not benefit from this research.
What this research studies
This research investigates the interactions between hantavirus glycoproteins and host cells, focusing on how these proteins are assembled and transported within the cell. By using advanced techniques like CRISPR-based screens, the study aims to uncover the mechanisms that allow hantaviruses to infect human cells and evade the immune response. The goal is to identify potential targets for antiviral therapies that could prevent or treat hantavirus infections, which currently have no FDA-approved treatments. Patients may benefit from insights gained into the development of new antiviral agents.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral treatments for hantavirus infections.
How similar studies have gone: While research on hantaviruses is ongoing, this specific approach to understanding glycoprotein assembly and host interactions is relatively novel and has not been extensively tested.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chandran, Kartik — Albert Einstein College of Medicine
- Study coordinator: Chandran, Kartik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.