Understanding how hair follicles reset for new hair growth
Regulation of catagen regression and progenitor pruning by the dermal sheath
This project looks at how hair follicles naturally shed old hair and prepare to grow new hair, which could help us understand hair loss and regeneration.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11124751 on NIH RePORTER |
What this research studies
The hair on our heads goes through a natural cycle of growing, resting, and shedding. This project explores how hair follicles manage this cycle, specifically focusing on the process where old hair sheds and the follicle prepares for new growth. Researchers are looking at specific cells and signals within the skin that tell hair follicles when to reset. By understanding these natural processes, we hope to learn more about why hair loss happens and how to encourage new hair to grow.
Who could benefit from this research
Good fit: Patients interested in the fundamental biology of hair growth and loss, or those with conditions related to hair cycle dysfunction, might find this research relevant.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a clinical trial would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat hair loss or promote hair regeneration by targeting the natural signals that control the hair cycle.
How similar studies have performed: While the hair cycle is well-studied, this project investigates a specific, previously unknown mechanism involving the dermal sheath in regulating progenitor death during hair regression, making this approach novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Rendl, Michael — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rendl, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.