Understanding how hair cells release neurotransmitters
Mechanisms of the calcium-triggered neurotransmitter release machinery in hair cells
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10866349
This study is looking at how a special protein called Otoferlin helps tiny hair cells in your ears send signals that are important for hearing and balance, which could help us understand more about conditions that affect these senses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10866349 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which hair cells in the auditory and vestibular systems release neurotransmitters, focusing on a protein called Otoferlin. The study employs molecular biology techniques, electrophysiological methods in zebrafish, and innovative membrane fusion assays to explore how Otoferlin facilitates this process. By examining the requirements for calcium, lipids, and other proteins in neurotransmitter release, the research aims to uncover the unique features of hair cell synaptic transmission. This could lead to a better understanding of hearing and balance disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with auditory or vestibular disorders, particularly those related to neurotransmitter release dysfunction.
Not a fit: Patients with non-auditory or non-vestibular conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of hearing and balance disorders, potentially leading to new treatments.
How similar studies have performed: While the specific mechanisms of Otoferlin in hair cells are less explored, similar approaches in studying neurotransmitter release have shown promise in other contexts.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZENISEK, DAVID PAUL — YALE UNIVERSITY
- Study coordinator: ZENISEK, DAVID PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.